Platinum-etoposide chemotherapy
Webb13 jan. 2024 · Based on results of the pivotal IMpower133 study, atezolizumab (anti–programmed death-ligand 1 [anti–PD-L1]) in combination with carboplatin and etoposide (CP/ET) was approved for the first-line treatment of extensive-stage small-cell lung cancer (ES-SCLC). Webb11 apr. 2024 · Platinum-based chemotherapy has been the standard first-line treatment for both limited-stage (LS) and extensive-stage (ES) disease since the 1980s, with an objective response rate (ORR) of about 65% and a one-year survival rate of 30%-40% for ES-SCLC ( …
Platinum-etoposide chemotherapy
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Webb10 apr. 2024 · Patients were eligible if they had: (i) biopsy-proven SCLC, (ii) stage IV disease, or (iii) treatment with platinum-etoposide chemotherapy alone (CT group) or in association with first-line PD-L1 inhibitors, atezolizumab, or durvalumab (CIT group). WebbPlatinum-based regimens, such as cisplatin/carboplatin plus etoposide/irinotecan are recommended therapy for SCLC as first-line chemotherapy treatment . Patients with SCLC are commonly categorized into sensitive or refractory relapse based on whether they responded to first-line chemotherapy.
WebbFor advanced or extensive stage SCLC, combined chemotherapy (platinum-etoposide) and immunotherapy (atezolizumab or durvalumab during and after chemotherapy) has become the new standard front-line treatment, with modest improvement in overall survival.
Webb5 apr. 2024 · This is a single arm, Phase II trial involving the use of atezolizumab plus platinum and etoposide for patients with locally advanced urothelial cancer. The primary … Webb4 sep. 2024 · Chemotherapy regimens containing platinum represent the cornerstone of treatment for patients with extensive disease, but there has been no real progress for 30 years. The evidence that SCLC is characterized by a high mutational burden led to the development of immune-checkpoint inhibitors as single agents or in combination with …
Webb2 feb. 2024 · Poorly differentiated neuroendocrine carcinomas account for 7–21% of digestive neuroendocrine neoplasms. , Platinum–etoposide chemotherapy is the first …
Webb28 feb. 2024 · In recent years, programmed cell death-ligand 1 (PD-L1) inhibitor plus platinum-etoposide chemotherapy was found to have favorable clinical outcomes in patients with extensive-stage SCLC (ES-SCLC). The usefulness of early tumor shrinkage (ETS) has been reported in various types of cancers. lower back spasms can\u0027t moveWebb13 juni 2024 · Based on this Phase II randomised trial, phased ipilimumab was investigated in the following Phase III study. 18 In this trial, 1,132 patients were assigned to a platinum/etoposide regimen for 4–6 cycles plus phased ipilimumab 10 mg/kg or placebo every 3 weeks followed by a maintenance phase of ipilimumab 10 mg/kg or placebo … horrific 911 callsWebb1 juli 2024 · Currently, programmed death-ligand 1 (PD-L1) inhibitor plus platinum-etoposide chemotherapy has been recognized as a standard treatment for patients with … lower back spasm recovery timeWebb7 dec. 2024 · Platinum (cisplatin or carboplatin) plus etoposide remains the backbone chemotherapy regimen for ES-SCLC. The prevalent model of combination therapy … lower back spasms when standingWebbBackground: Patients with limited-stage (ls) or extensive-stage (es) small-cell lung cancer (sclc) are commonly given platinum-based chemotherapy as first-line treatment. Standard chemotherapy for patients with ls sclc includes a platinum agent such as cisplatin combined with the non-platinum agent etoposide. lower back spasm exercisesWebb28 okt. 2024 · Although 74% of the patients in the atezolizumab group had received previous 1L cycle of platinum-etoposide treatment (21% being cisplatin-etoposide), the mOS was not statistically different in those who received cisplatin-etoposide versus carboplatin-etoposide chemotherapy (mOS = 9.8 versus 13.3 mo, p = 0.21). Radiation … lower back spasms remedyWebb6 juli 2024 · Phase II Trial of Platinum-Etoposide Chemotherapy and Durvalumab (MEDI4736) With Sub-Ablative SBRT in Patients With Newly Diagnosed Stage IV Small … horrific accident death