Web11β-HSD2基因的表达量在注射后48 h,7 d、14 d时均与对照组存在显著差异(P0.05),其中7 d时降至最低;P450scc基因和P450arom基因的表达量均在注射后48 h时表达量降至最低,且与对照组存在显著差异(P0.05)。实验结果表明,MT可能是通过调节P450scc基因水平来降低P450arom的表达量,而 ... Web目的 1.测定PCOS组与正常对照组患者卵巢颗粒细胞P450arom和PPARy基因表达及Smad2、p-Smad2蛋白的表达水平。 2.探讨卵巢颗粒细胞PPARy和P450arom基因表达与Smad2蛋白及其磷酸化水平之间的相关性,为进一步研究卵巢颗粒细胞PPARy对P450arom表达的调控途径提供前期基础。 材料与方法 本实验选取了2012年11月~2013年2月在郑州大学第一附 …
CYP11A1 Gene - GeneCards CP11A Protein CP11A …
WebP450scc基因位于第15号染色体(15q23q24),结构基因突变尚未鉴定,酶缺陷是常染色体隐性遗传,推测是基因点突变所致。P450scc基因缺陷使胆固醇转变为孕烯醇酮受阻, … WebBELLA Italia Ristorante. 13848 Tilden Rd #192, Winter Garden, FL 34787. We were meeting old friends and wanted to share a long lunch reminiscing. The staff was wonderful in … is it legal to own a pet owl
生物技术通报,2016,32(1): 163-168 - html.rhhz.net
Cholesterol side-chain cleavage enzyme is commonly referred to as P450scc, where "scc" is an acronym for side-chain cleavage. P450scc is a mitochondrial enzyme that catalyzes conversion of cholesterol to pregnenolone. This is the first reaction in the process of steroidogenesis in all mammalian … See more The highest level of the cholesterol side-chain cleavage system is found in the adrenal cortex and the corpus luteum. The system is also expressed at high levels in steroidogenic theca cells in the ovary, and Leydig cells in … See more P450scc catalyzes the conversion of cholesterol to pregnenolone in three monooxygenase reactions. These involve 2 hydroxylations of the cholesterol side-chain, which … See more Mutations in the CYP11A1 gene result in a steroid hormone deficiency, causing a minority of cases of the rare and potentially fatal condition lipoid congenital adrenal hyperplasia. … See more • Steroidogenic enzyme • Cytochrome P450 oxidase See more In each steroidogenic cell, the expression of the P450scc system proteins is regulated by the trophic hormonal system specific for the cell type. In adrenal cortex cells from zona fasciculata, the expression of the mRNAs encoding all three P450scc proteins is induced by See more Cholesterol side-chain cleavage enzyme inhibitors include aminoglutethimide, ketoconazole, and mitotane, among others. See more • Helmberg A (August 1993). "Twin genes and endocrine disease: CYP21 and CYP11B genes". Acta Endocrinologica. 129 (2): 97–108. doi:10.1530/acta.0.1290097. PMID 8372604. • Papadopoulos V, Amri H, Boujrad N, Cascio C, Culty M, … See more Web另一方面,酶合成涉及到酶的使用,如细胞色素P450scc和CYP27A1。这些酶催化胆固醇氧化为25-羟基胆固醇。 ... 它已被证明具有多种药效学作用,包括调节基因表达、抗炎、抗凋亡和抗氧化作用。 ... Web25-羟胆固醇能显著抑制StAR和SREBP-2基因mRNA的表达水平,不同处理浓度对P450scc基因的mRNA表达影响不显著,但有一定的抑制趋势,对STARD4基因mRNA表达却有一定的促进作用。 (5)添加Mevinolin对颗粒细胞活性有一定的抑制作用,对颗粒细胞孕酮的分泌影响不明 … ketamine psychiatrist near me