Web7 jun. 2024 · Several small-molecule compounds, including abemaciclib, are inducers of methuosis, which display dramatic anti-tumor activities (Robinson et al., 2012; Huang et … Web19 jan. 2024 · Hyperactivated macropinocytosis caused by certain abnormally activated genes such as K-RAS and certain specific small molecule drugs such as MIPP may induce a novel form of cell death distinct from apoptosis: methuosis.
【Methuosis inducer 1】Methuosis inducer 1 CAS号:2240205 …
Web28 jan. 2024 · HZX-02-059 was identified as a methuosis inducer with strong vacuolation ability in our previous studies, but its target was unclear. During the further investigation … WebMethuosis was originally described in glioblastoma cells after the ectopic expression of activated Ras (rat sarcoma virus) [4] and small molecules that induce methuosis in numerous cancer cell types have been described, including apoptosis-resistant cancer cells. hat is mutual respect and tolerance of others
A working model for MIPP-induced methuosis suggested by the …
WebMost known inducers of transient vacuolization are weakly basic amine-containing lipophilic compounds. In neutral extracellular fluid, lipophilic bases are uncharged and can be transported through the plasma membrane via passive diffusion or active transport [9, 10]. Web2 dagen geleden · A novel methuosis inducer DZ-514 possesses antitumor activity via activation of ROS-MKK4-p38 axis in triple negative breast cancer - 科研通 已完结 上个求 … WebUniversity of Vienna. Okt. 2015–Heute7 Jahre 7 Monate. Vienna. Fellowship Programme, co-funded by the EU Framework programme 7 (FP7) Marie Curie Actions. Funded Project: 'Resensitisation of chemotherapy resistant cancer cells through selective inhibition of the STAT3 signalling pathway'. • Drug-Discovery, biological evaluation and ... boots party supplies