Mechanisms of resistance to cisplatin
WebJan 20, 2024 · Resistance to platinum-containing drugs has been associated to several mechanisms, including alteration in drug efflux (through for example the modulation of the copper transporter CTR-1 expression) [1,2,3,4,5], alteration in intracellular proteins able to bind and sequester Pt (as for example GSH) [6,7,8,9], and altered expression of … WebThe first is the reduction in the accumulation of the drug intracellular. 17 Reduced accumulation of drug is a significant mechanism that results into resistance and reductions in accumulation of drugs by a factor of between 20% to70% could cause resistance of cisplatin by a factor of 3 to 40 fold respectively. 18 However as Koberle et al ...
Mechanisms of resistance to cisplatin
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WebMar 22, 2024 · EMT-associated chemotherapy resistance in SCC. To investigate the role and the mechanisms of resistance to therapy in EMT tumour cells in vivo, we used a genetically induced mouse model of skin SCCs combining the expression of oncogenic Kras (Kras G12D) with the deletion of Trp53 and the expression of a YFP reporter in hair follicle … WebAug 1, 2001 · One established mechanism for cisplatin resistance is evasion of cell apoptosis following long-term use of cisplatin (10), which results in resistance to …
http://connectioncenter.3m.com/cisplatin+research+paper WebApplications of Machine Learning to Predict Cisplatin Resistance in Lung Cancer . Fulltext; Metrics; Get Permission; Cite this article; Authors Gao Y, Lyu Q, Luo P , Li M, Zhou R, Zhang …
WebFeb 28, 2024 · However, the principal mechanisms by which 13 and, above all, 18 overcome cisplatin resistance rely on three different possible mechanisms: the inhibition of endogenous P-gp expression, a transporter that enables the active efflux of the drug from the cancer cells; the generation of ROS inside the cells that can reduce GSH levels, a … WebMechanisms associated with the expression of cisplatin resistance in a human ovarian tumor cell line following exposure to fractionated X-irradiation in vitro. Carcino-genesis 13: …
WebMar 28, 2024 · Objective: Cisplatin resistance development is a major obstacle in ovarian cancer treatment. One of the most important mechanisms underlying cisplatin resistance is drug detoxification by glutathione.
WebSep 24, 2024 · Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, generating genetic and epigenetic changes that lead to the generation of resistance and the activation of intrinsic resistance mechanisms in cancer cells. Among them, we can find mutations, … dead phone sellWebJun 26, 2024 · It may be considered as one of the mechanisms of resistance to cisplatin-mediated cell death. Fig. 2: Signal transduction cascades mediating nonapoptotic forms of cell death induced by... dead phone not chargingWebJul 28, 2024 · Inside the tumor cell, decreased drug import, increased drug export, increased drug inactivation by detoxification enzymes, increased DNA damage repair, and inactivated cell death signaling are major mechanisms leading to cisplatin resistance. dead photographersWebFeb 27, 2013 · Decreased cellular uptake of cisplatin by resistant cells is one of the major mechanisms of resistance described in vitro. The mechanism responsible for reduced cisplatin accumulation in resistant cells may be ascribed to either an inhibition in drug uptake, an increase in drug efflux, or both. dead photo filterWebMechanisms of resistance to cisplatin Alan Eastman Chapter 115 Accesses 29 Citations Part of the Cancer Treatment and Research book series (CTAR,volume 57) Abstract Cisplatin has become a major clinical drug because of its … dead phone screenWebPostulated mechanisms of cisplatin drug resistance include decreased intracellular accumulation of cisplatin, increased intracellular levels of certain sulfur-containing macromolecules, and increased DNA repair. 1,3. Decreased Intracellular Accumulation If cisplatin cannot accumulate in the cell, it cannot reach the DNA found inside the cell ... generac g0071320 power washer partsWebApr 12, 2024 · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need alternative therapy options. Researchers at ... generac g065795 battery charger rectifier