WebSep 26, 2009 · There is no true antidote for TCA overdose, but this EKG screams for intravenous sodium bicarbonate, alkalinization of the serum, aggressive sedation for … WebKey Points. Most morbidity and mortality from tricyclic overdose are within the first 6 hours as a result of hypotension and cardiac arrhythmias. Serial ECG monitoring can guide when to initiate bicarbonate boluses. Contact Poison Control (800-222-1222) or Medical Toxicology consult (415-443-0122) for assistance.
Anticholinergic intoxication - EMCrit Project
WebNov 21, 2024 · Toxicity. Tricyclic antidepressants (TCAs) generally have a narrow therapeutic index and, therefore, are prone to induce toxicity if intentional overdose occurs. ... Overdose symptoms include ECG abnormalities such as QTc prolongation and widened QRS complex, hypotension, seizures, tremors, coma, xerostomia, urinary retention, ... WebApr 26, 2024 · Improvement in EKG findings following administration of bicarbonate supports the presence of sodium channel blockade. In a patient who overdosed on a … rapp \u0026 nogen
Crit Cases Massive TCA Overdose EM Cases
WebOverdoses of tricyclic antidepressants are among the commonest causes of drug poi-soning seen in accident and emergency departments. This review discusses the pharmacokinetics, clinical presentation and treatment of tricyclic overdose. (Emerg Med J 2001;18:236–241) Keywords: tricyclic antidepressant; overdose The first report of … WebAbstract. The tricyclic antidepressant (TCA) agents are recognized for their potentially lethal cardiovascular and neurological effects in poisoned patients. The 12-lead … WebAug 23, 2012 · Tricyclic antidepressants remain a common cause of fatal drug poisoning as a result of their cardiovascular toxicity manifested by ECG abnormalities, arrhythmias and hypotension. Dosulepin and amitriptyline appear to be particularly toxic in overdose. The principal mechanism of toxicity is cardiac sodium channel blockade, which increases the … rapp \u0026 rapp